- The tissue may become less responsive to the hormone as the number of receptors for the hormone may decrease
- If there is no change in receptor number there may be a changed in the signalling system within the cell – e.g. a reduction in production of one of the secondary messenger molecules to reduce to the response to the hormone
Q7. A tissue that has been responsive to hormone X may, over time, lose its response to hormone X, even though the concentration of hormone X remains unchanged